Histopathological Evaluation of Toxic Effect of Oral Administration of African Black Soap (Sabulun salo) on the Kidney of Albino Rats

Abstract

African traditional black soap (Sabulun salo) is commonly used in many local settings in Nigeria. The aim of this study was to determine the histopathological evaluation of toxic effect of oral administration of the African traditional black soap (Sabulun salo) on the kidney of Albino rats. The albino rats were divided into four groups of five per test groups and a control group. The test groups (AC, BC and FC) were administered with the different concentration (2000mg/kg, 3000mg/kg and 4000mg/kg) of African traditional black soap (Sabulun salo) for the period of two weeks respectively. The control group received normal saline. At end of the intervention, the animals were sacrificed, and the kidneys were processed for paraffin embedding. The blood samples were collected for biochemical and haematological analysis. The kidney presented a normal histo-morphology across all the groups. The haematological and biochemical analysis showed some significant changes in the entire groups. There was a reduction in water and food consumption as the concentrations increased. There was a significant increase in white blood cell, haemoglobin and packed cell volume in the entire groups except in group FC when compared to the control. There were haphazard changes in the blood biochemical parameters. The results of this research have shown that the African traditional black soap (Sabulun salo) is histologically non -toxic to the kidney of the albino rats exposed.