Evaluation of Physicochemical Properties of Some Orthodox Antimalarials Used In South –East, Nigeria.

Abstract

Oral bioavailability of drug is determined by its physicochemical properties which governs its rate limiting release at the gastrointestinal tract for absorption into the systemic circulation. We conducted pilot study of physicochemical properties (colour, size, molecular weight, dissolution time, pH solubility and specific gravity) of few selected antimalarial agents of 2 to 5 different brands (trade name), but the same generic from 4 different makes. Our pilot study showed variability in physicochemical properties, both intra and inter differences. The need, therefore, to maintain good clinical pharmacological practice to ensure safety and potency of antimalarial agents and to prevent Plasmodium parasite resistance.