Qualitative Defect of Platelets And Its Effect on Blood Coagulation: A Mini Review

Abstract

Qualitative platelet defects are a group of disorders characterized by impaired platelet function, despite normal or near-normal platelet counts. Platelets are well known for their primary role in haemostasis which is a crucial part of human existence and survival. The qualitative defects of platelets result in bleeding complications in patients suffering from this disorder due to compromised platelet functions that may not be associated with the quantity of platelets in circulation but the quality of these platelets. Usually, in the hospital, clinicians usually do not focus on this aspect of coagulation disorder but rather more attention and focus are placed on the quantitative aspect of the platelets. The aim of this review is to provide an in-depth view of the types, how we diagnose, some management plans of qualitative platelet defects, with a focus on the effects that qualitative defects of platelets has on blood coagulation. This review will therefore cover inherited and acquired disorders, such as Glanzmann thrombasthenia, Bernard-Soulier syndrome, drug-induced platelet dysfunction etc... The diagnostic methods for qualitative platelet disorders in the medical laboratory which include platelet aggregation test shall also be highlighted among other discussions . Additionally, current management options, including pharmacological interventions and platelet transfusions, will also be explored.