The Effect of Combined Aqueous Extract of Turmeric and Curry Leaves on Haematological parameters and Histology of the Lungs in High Salt fed Wistar Rat.

Abstract

This study investigated the effect of combined aqueous extract of Turmeric and curry leaves extract on the Haematological parameters and histology of the lungs in high salt fed Wistar rats. A total of 36 male Wistar rats were selected and they were randomly divided into 6 groups of 6 animals each. After acclimatization for 14 days, group one served as the control, and received no treatment other than food and water. Group two; received salt (8%). Group three received salt and vitamin C, group four received a low dose of the extract with salt, group five received medium dose of the extract and salt, group six received high dose of the extract and salt. The administration was done once daily for 28 days. Twelve animals were sacrificed on the 14th and 28th day respectively. Blood samples and lungs were collected from each animal to analyze the haematological parameters and histology of the lungs respectively. The results of this study showed that antioxidant levels are present in turmeric and curry leaves, and vitamin C is able to reduce the damaging effect of high salt intake on the lungs of Wistar rats. The results of this study show that high salt intake causes an increase on haematological parameters, combined extract of turmeric and curry leaves help reverse its increase.