Effects of Honey on Some Haematological Indices and Lipid Profile in Male Mice

Abstract

This study was primarily designed to investigate the effect of acute administration of honey on some haematological parameters and lipid profile parameters of male mice. Fifteen male mice were divided into five groups of three each and were administered with distilled water, 10%, 20%, 50%, and 100% (v/v) of pure honey daily for seven days in that order. On the eighth day the mice were sacrificed and blood samples were collected for analyses. Total cholesterol, HDL, LDL, Triglyceride level and complete blood counts were determined by automatic analyzer. Low density lipoprotein (LDL) and Total cholesterol levels was observed to be higher in the mice treated with 10% (v/v), 20% (v/v), 50% (v/v) and 100% (v/v) compared to the control group (p < 0.05). However, HDL levels in mice treated with 10% v/v, 50% v/v and 100% v/v were higher (p > 0.05) but 20% (v/v) was slightly lower as compared to the control group. Group 5 [100% (v/v)] was higher as compared to group 2 (10% v/v) and group 4 [50% (v/v)]. Triglyceride levels showed decrease (p > 0.05) in the rest of the group as compared to the control group. There was increase (p > 0.05) MID (monocyte count) with increasing concentration and increase in Platelet count in Group 2 [10% (v/v)] as compared to the other groups. Hb, PCV and RBCs Count were higher (p > 0.05) in Group 2 [10% (v/v)] as compared to the rest of the groups. Results from this study suggest that daily consumption of honey might have some positive effects on haematological indices and triglyceride levels.