Effect of Methanolic Leaf Extract of Solanum incanum on Full Blood Count Parameters in Wistar Rats

Abstract

The plant called Solanum incanum is known for its medicinal properties, including its ability to boost blood. The various phytochemical components of Solanum incanum are thought to have therapeutic impacts on blood-related parameters. These effects have not been rigorously examined through scientific studies to validate and confirm the therapeutic assertions regarding their effect on red bloods, white blood cells and platelets. The aim of this study was to determine the effects of methanolic leaf extract of Solanum incanum on full blood count in Wistar rats. The experimental Wistar rats groups were administered with methanolic leaf extracts of Solanum incanum at dose of 500mg/kg and 1000 mg/kg orally once per day for a period of fourteen days. Blood of 3 mL was collected from each rat into an EDTA tube, red blood cells, white blood cells and platelets parameters were determined using three parts haematology analyzer (Rayto 7200, China). Phytochemicals constituents were determined using standard methods. Fourteen days after administration of methanolic leaf extracts of Solanum incanum at the dose level of 500 mg/kg and 1000mg/kg there was significant increase in white blood cell count (WBC) and Neutrophils. There was no statistically significant difference in red blood cell count (RBC), platelet count and their indices but a slight increase was observed in their mean values compared to the controls. In conclusion, the methanolic leaf extract of Solanum incanum had phytochemicals that significantly increase white blood cells counts but red blood cells and platelets were not significantly increase.